Moberly is a regional hub serving as a crossroads for east/west railroad freight and is a crossroads for highway travel as well. Its location on the main north/south corridor of Missouri, 4-lane U.S. Highway 63, provides Moberly with excellent connections on the south to Interstate 70 and 4-lane U.S. Highway 36 to the north. U.S. Highway 24 offers a convenient connection to Hannibal, Quincy, and Chicago on the east and Kansas City on the west. Moberly is 35 miles from Columbia; 140 miles from Kansas City; and a 155 mile drive from St. Louis.

Corporate jets and propeller driven aircraft use Moberly’s Omar Bradley Airport, located on the northern edge of the city. It has two lighted, paved runways of 3,730 and 4,680 feet (soon to be 5,000 feet).

Shipping needs for the city’s business and industry are met by Norfolk/Southern, and by several 24 hour motor freight carriers and package delivery services.

Taxi service and Magic City Express buses provide door-to door transportation in Moberly.