Moberly is a regional hub serving as a crossroads for east/west railroad freight and is a crossroads for highway travel as well. Its location on the main north/south corridor of Missouri, 4-lane U.S. Highway 63, provides Moberly with excellent connections on the south to Interstate 70 and 4-lane U.S. Highway 36 to the north. U.S. Highway 24 offers a convenient connection to Hannibal, Quincy, and Chicago on the east and Kansas City on the west. Moberly is 35 miles from Columbia; 140 miles from Kansas City; and a 155 mile drive from St. Louis.

Corporate jets and propeller-driven aircraft use Moberly’s Omar Bradley Airport, located on the northern edge of the city. It has two lighted, paved runways of 3,730 and 5,000 feet with a parallel taxiway which easily accommodates corporate jets. With a newly remodeled terminal with pilot lounge and the latest technology, Omar Bradley Airport is a regional airport designation.

Shipping needs for the city’s business and industry are met by Norfolk/Southern, and by several 24 hour motor freight carriers and package delivery services.

Taxi service and Magic City Express buses provide door-to-door transportation in Moberly.